Search results for "dopaminergic system"

Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish

2022

Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription factors. Genetic variation within the ANKK1 locus is suggested to play a role in vulnerability to addictions. However, ANKK1 mechanism of action is still poorly understood. It has been suggested that ANKK1 may affect the development and/or functioning of dopaminergic pathways. To test this hypothesis, we generated a CRISPR-Cas9 loss of function ankk1 zebrafish line causing a 27 bp insertion that disrupts the ankk1 sequence introducing an early stop codon. We found that…

The role of the dopaminergic system in gratification processes.

2013

POSTNATAL DEVELOPMENTAL CHANGES IN ENTERIC DOPAMINERGIC SYSTEM

2013

The postnatal period is a key period of life, characterized by the maturation of various organs and in particular of the gut. Currently, we have a poor understanding of the development of neurological and endocrine factors that control intestinal motility. Such knowledge can provide indications about the potency, efficacy, or therapeutic range of a drug in premature infants. Dopaminegic antagonists are often used as prokinetic drugs to treat impaired GI propulsion, although the role of the enteric dopaminergic system in the control of intestinal motility in neonatal vs adult has not been adequately addressed. In this view the aim of this study, was to examine, the functionality of the dopam…